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The pharmacokinetics of the Metadate 20mg ER methylphenidate hydrochloride formulation have been studied in healthy adult volunteers and in children with Attention Deficit Hyperactivity Disorder (ADHD).
Metadate 20mg ER is contraindicated in patients with marked anxiety, tension and agitation, since the drug may aggravate these symptoms.
Hypersensitivity To Methylphenidate Or Other Excipients
Metadate 20mg ER is contraindicated in patients known to be hypersensitive to methylphenidate or other components of the product.
Metadate 20mg ER contains sucrose. Therefore, patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption, or sucrase-isomaltase insufficiency should not take this medicine.
Metadate 20mg ER is contraindicated in patients with glaucoma.
Metadate 20mg ER is contraindicated in patients with motor tics or with a family history or diagnosis of Tourette’s syndrome (ADVERSE REACTIONS).
Monoamine Oxidase Inhibitors
Metadate 20mg ER is contraindicated during treatment with monoamine oxidase inhibitors, and also within a minimum of 14 days following discontinuation of a monoamine oxidase inhibitor (hypertensive crises may result).
Hypertension And Other Cardiovascular Conditions
Metadate 20mg ER is contraindicated in patients with severe hypertension, angina pectoris, cardiac arrhythmias, heart failure, recent myocardial infarction, hyperthyroidism or thyrotoxicosis.
There is a risk of sudden blood pressure increase during surgery. If surgery is planned, Metadate 20mg ER should not be taken on the day of the surgery.